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Dion Kai Dickman

Assistant Professor

Dion Kai Dickman

Research Topics

  • Synapse development, function, and plasticity in Drosophila

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Research Overview

We are interested in synapse development, function, and plasticity in general, and in particular how these processes are stably maintained within proper physiological ranges, referred to as homeostatic synaptic plasticity. Homeostatic feedback systems are a ubiquitous form of biological regulation, which recently have been demonstrated to maintain the stability of nervous system function. Homeostatic processes also play crucial roles in the development of the nervous system, tuning synaptic strength and establishing the proper balance of excitation and inhibition. Dysfunction in these systems may contribute to the etiology of schizophrenia, autism, epilepsy, and other complex neurological and psychiatric diseases. Our long term interests are to identify the molecules and elucidate the mechanisms that achieve and maintain the stability of neural function, and to determine how dysfunction in these processes may contribute to human disease.

We use the fruit fly Drosophila melanogaster as a model system because of its amenability to advanced genetic, molecular, electrophysiological, imaging, and cell biological approaches. Using an electrophysiology-based forward genetic screen, we have isolated several novel genes that are required for adaptive plasticity, including one, dysbindin, which has been linked to schizophrenia in humans. We are currently characterizing other novel genes and performing further screens with the goal of illuminating the molecular, cellular, and synaptic mechanisms governing this complex, fundamental and poorly understood process.

Contact Information

Mailing Address University of Southern California
University Park Campus
3641 Watt Way
HNB 309 M/C 2520
Los Angeles, CA 90089-2520
Office Location HNB 309
Office Phone (213) 740-7533
Lab Location HNB 309
Lab Phone
Fax
Office Location HNB 309

Websites

Education

  • PhD, Harvard University
  • Post-doctoral training: UCSF

Selected Publications

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