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Takahiro Ohyama

Assistant Professor of Research

Takahiro  Ohyama

Research Topics

  • How is the inner ear induced?
  • How are sensory and non-sensory regions of the cochlea specified?

Research Overview

Hearing loss is one of the most common birth defects. Approximately one in five hundred newborns suffer from significant hearing impairment. In addition, once mechanosensory hair cells in the inner ear are damaged and lost by any of a variety of reasons such as aging and loud noises, they never regenerate. Thus, majority of sensorineural hearing loss, such as age-related hearing loss and noise-induced hearing loss is permanent and significantly affect the quality of one’s life. Recently, stem cell research has shed light on the possibility of regeneration of hair cells in humans. Our research goal is to understand the molecular mechanisms of inner ear development and to explore the possibility of regenerating sensory cells to treat hearing and balance disorders.

Contact Information

Mailing Address 1501 San Pablo Street, ZNI 435
Los Angeles, CA 90033-4503
Office Location ZNI 435
Office Phone
Lab Location ZNI 413
Lab Phone
Fax
Office Location ZNI 435

Education

  • Ph.D. at Kyoto University, Japan (2001)
  • B.S. at Kyoto University, Japan (1996)

Selected Publications

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  • Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. (2010). BMP signaling is necessary for patterning the sensory and non-sensory regions of the developing mammalian cochlea. J. Neurosci. 30(45): 15044-15051.
  • Ohyama T. (2009). Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice. Brain Research 1277: 84-89
  • Jayasena CS, Ohyama T, Segil N, Groves AK. (2008). Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development 135: 2251-2261
  • Ohyama T, Groves AK, Martin K. (2007). The First Steps Towards Hearing: Mechanisms of Otic Placode Induction. Int. J. Dev. Biol. 51: 463-472
  • Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK. (2006). Wnt signals mediate a fate decision between otic placode and epidermis. Development 133: 865-875
  • Ohyama T, Groves AK. (2004). Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn 231: 640-646
  • Ohyama T, Groves AK. (2004). Generation of Pax2-Cre Mice by Modification of a Pax2 Bacterial Artificial Chromosome. genesis 38(4): 195-199