Browse Faculty A-Z

Hong-Wei Dong

Associate Professor, Neurology
Institute for Neuro Imaging
Zilkha Neurogenetic Institute
Keck School of Medicine of USC

Research Topics

  • Brain atlasing
  • Neuroanatomy and Connectomics
  • High throughput image analysis and visualization tools

Research Overview

The Dong Lab undertakes several projects related to characterizing the neural architecture of mouse models of health and disease and creating open-access data resources and informatics pipelines for mouse brain atlasing. Our Mouse Connectome Project (MCP) (www.MouseConnectome.org) aims to create a three-dimensional, Google Earth-like, digital Connectome atlas of the C57BL/6J mouse brain. We have well-established state of the art tract-tracing technologies to systematically reveal and map neuronal networks of the whole mouse brain, and have developed a high-throughput pipeline for data production, collection, and analysis. These large-scale, high-resolution, high-quality raw imaging data are made freely accessible to the neuroscience community and general public. To facilitate their use, we have also developed a powerful visualization tool that enables users to visualize and annotate these data.

Recently, we constructed a mouse cortico-striatal projectome: a comprehensive projection map from the entire cortex to the dorsal striatum in the mouse. We use this connectomics approach to characterize circuit-specific cortico-striatal connectopathies in mouse models of disconnection syndromes such as autism spectrum disorder and Huntington disease.

Contact Information

Mailing Address
Office Location ZNI 307
Office Phone (323) 442-1100
Lab Location
Lab Phone
Fax
Office Location ZNI 307

Websites

Education

  • 1999 - Ph.D., the Fourth Military Medical University (Xian, China) (Research project for PhD thesis was conducted at University of Southern California)
  • 1996 - M.S., the Fourth Military Medical University (Xian, China), (Neuroscience)
  • 1993 - M.D., the Fourth Military Medical University (Xian, China), (Medicine)

Selected Publications

  • Hintiryan, H., Foster, N. N., Bowman, I., Bay, M., Song, M. Y., Gou, L., ... & Yang, X. W. (2016). The mouse cortico-striatal projectome. Nature Neuroscience.
  • Condro, M. C., Matynia, A., Foster, N. N., Ago, Y., Rajbhandari, A. K., Van, C., ... & May, V. (2016). High‐resolution characterization of a PACAP‐EGFP transgenic mouse model for mapping PACAP‐expressing neurons. Journal of Comparative Neurology, 524(18), 3827-3848.
  • Zingg, B., Hintiryan, H., Gou, L., Song, M. Y., Bay, M., Bienkowski, M. S., ... & Dong, H. W. (2014). Neural networks of the mouse neocortex. Cell, 156(5), 1096-1111.