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Christian J. Pike

Professor
Davis School of Gerontology

Christian J. Pike

Research Topics

  • Regulation of Alzheimer's disease pathogenesis
  • The role of sex steroid hormones in Alzheimer's disease
  • Relationships between obesity, type 2 diabetes, and Alzheimer's disease
  • Signaling pathways regulating neuronal apoptosis and neuroprotection

Research Images

Double-immunolabeling with beta-amyloid (brown) and hyperphosphorylated tau PHF-1 (dark blue) shows amyloid plaques and neurofibrillary tangles, respectively, in an Alzheimer's brain.
Double-immunolabeling with beta-amyloid (brown) and hyperphosphorylated tau PHF-1 (dark blue) shows amyloid plaques and neurofibrillary tangles, respectively, in an Alzheimer's brain.
Primary culture of rat hippocampal neurons stained with the fluorescent vital dye calcein AM. Note the presence of numerous, finely branched neurites.
Primary culture of rat hippocampal neurons stained with the fluorescent vital dye calcein AM. Note the presence of numerous, finely branched neurites.
Immunolabeling for hyperphosphorylated tau (AT8; brown) shows an example of neuronal pathology in hippocampus of a triple transgenic mouse model of Alzheimer's disease.
Immunolabeling for hyperphosphorylated tau (AT8; brown) shows an example of neuronal pathology in hippocampus of a triple transgenic mouse model of Alzheimer's disease.
Primary cultures of rat astrocytes develop a reactive phenotype (evidenced here with a process-bearing morphology) when treated with beta-amyloid, the protein implicated in neurodegenerative cascades of Alzheimer's disease. Cultures were immunostained with GFAP (red).
Primary cultures of rat astrocytes develop a reactive phenotype (evidenced here with a process-bearing morphology) when treated with beta-amyloid, the protein implicated in neurodegenerative cascades of Alzheimer's disease. Cultures were immunostained with GFAP (red).

Research Overview

Research in my lab is broadly focused on Alzheimer's disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational approaches that will be useful in the prevention and/or treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, wild-type and transgenic rodent models, and cultured cells.

One area of focus in my laboratory is studying how the development of AD is affected by sex differences and the sex-specific loss of steroid hormones during aging. For example, our research with postmortem human brain has helped to identify testosterone loss in aging men as a risk factor for AD. In rodent models, we observe that depletion of androgens accelerates development of AD-related neuropathology and increases neuronal vulnerability to toxic insult. We use cell culture studies to identify the relevant underlying mechanisms for these androgen effects, including investigation of classic genomic actions as well as activation of rapid cell signaling pathways. In ongoing translational studies, we are building upon our basic science advances to develop specific therapeutic interventions that selectively activate protective androgen pathways (e.g., TSPO ligands, synthetic testosterone mimetics). Using this general research strategy, we are pursuing conceptually parallel basic science and translational projects to evaluate the interactions between estrogen and progesterone actions in the regulation of neurodegenerative cascades associated with AD in females.

A second area of research in the lab seeks to understand the relationships between obesity, type 2 diabetes, and AD. Epidemiological findings have identified obesity in middle age, and its downstream consequences metabolic syndrome and type 2 diabetes, as significant risk factors for the development of AD in old age. Our efforts are focused at understanding the mechanistic links between these conditions, including the interactive roles of adiposity, neuroinflammation, and age-related changes in testosterone and estrogen. Current areas of investigation are elucidating how the deleterious neural effects of obesity (i) differ by sex, and (ii) interact with APOE4 and other AD genetic risk factors.

Contact Information

Mailing Address University of Southern California
Davis School of Gerontology
3715 McClintock Avenue
Los Angeles, CA 90089-0191
Office Location GER 306C
Office Phone (213) 740-4205
Lab Location GER 304
Lab Phone (213) 740-8244
Fax
Office Location GER 306C

Websites

Education

  • BS, University of Southern California, 1985
  • PhD, University of California Irvine, 1994
  • Postdoctoral Fellow, University of California Irvine, 1995

Selected Publications

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  • Moser VA, Pike CJ (2017) Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice. eNeuro In press.
  • Christensen A, Pike CJ (2017) Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice. PLoS ONE. In press.
  • Jayaraman A, Lent D, Pike CJ (2014) Diet-induced obesity and low testosterone increase neuroinflammation and reduce neuron survival. J Neuroinflammation 11 (1): 162.
    PubMed
  • Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, and Pike CJ (2013) Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci 33 (20): 8891-8897. PubMed
  • Barron AM, Rosario ER, Brown MA, Eltereifi R, and Pike CJ (2013) Sex-specific effects of high-fat diet on indices of metabolic syndrome in 3xTg-AD mice: Implications for Alzheimer's disease. PLoS ONE 8 (10): e78554.
  • Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, and Pike CJ (2012) 17beta-Estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 153 (11): 5467-5479. PubMed
  • Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ (2011) Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging. 32 (4): 604-613. PubMed
  • Pike CJ, Carroll JC, Rosario ER, Barron AM (2009) Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol. 30(2):239-258. PubMed
  • Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 27(48):13357-1336.  PubMed
  • Yao M, Nguyen TV, Pike CJ (2007) Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. J Neurosci. 27(6):1422-1433. PubMed