Browse Faculty A-Z

Kathie Eagleson

Associate Professor of Research Pediatrics, Cell & Neurobiology

Kathie  Eagleson

Research Topics

  • Development of Neuronal Diversity, Neural Circuitry and Synapses in Neocortical Networks
  • Impact of early adverse experience on brain development
  • Influence of sex on response to early life stress

Research Overview

Research projects investigate the mechanisms that underlie the development of normal brain architecture. There are two primary focuses. The first examines the role of the MET tyrosine kinase receptor in synapse development. Disruptions in the expression of this receptor are associated with an increased risk for autism spectrum disorder and Rett syndrome. Currently, we are using a quantitative proteomics approach to measure changes in the mouse neocortical and striatal synaptic proteome in the absence of MET signaling. The second measures the sex-dependent effects of early life stress on the developing brain. Specifically, we are using proteomics, biochemical and anatomical approaches to determine acute (before puberty) and long-term (adult) adaptive responses in mitochondrial and glial function following early life stress.

Contact Information

Mailing Address The Saban Research Institute
4650 Sunset Blvd., Mailstop # 135
Los Angeles, CA 90027
Office Location CHL 307 TSRI
Office Phone (323) 361-7564
Lab Location CHLA
Lab Phone
Fax
Office Location CHL 307 TSRI

Education

  • BSc (Hons), University of Sydney, Australia
  • PhD, Neurobiology, University of Sydney, Australia
  • Postdoctoral Fellow, University of Southern California
  • Postdoctoral Fellow, Medical College of Pennsylvania

Selected Publications

  • Eagleson, K.L., Lane, C.J., McFadyen-Ketchum, L., Solak, S., Wu, H.H. and Levitt P: Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis. Dev. Neurobiol. 76:1160-1181, 2016. PubMed
  • Eagleson, K.L., Xie, Z. and Levitt, P: The pleiotropic MET receptor network: circuit development and the neural-medical interface of autism. Biol. Psychiatry. 2016. PubMed
  • Xie, Z., Eagleson, K.L., Wu, H.H. and Levitt, P: Hepatocyte Growth Factor modulates MET receptor tyrosine kinase and b-catenin functional interactions to enhance synapse formation. eNeuro. 2016. PubMed
  • Xie, Z., Li, J., Baker, J., Eagleson, K.L., Coba, M.P. and Levitt, P: Receptor tyrosine kinase MET interactome and neurodevelopmental disorder partners at the developing synapse. Biol. Psychiatry 80:933-942, 2016. PubMed
  • Wang, F., Eagleson, K.L. and Levitt, P: Positive regulation of neocortical synapse formation by the Plexin-D1 receptor. Brain Res. 1616:157-165, 2015 (co-first author). PubMed
  • Eagleson, K.L., Milner, T.A., Xie, Z. and Levitt, P: Synaptic and extrasynaptic location of the receptor tyrosine kinase Met during postnatal development in the mouse neocortex and hippocampus. J. Comp. Neurol. 521:3241-3259, 2013. PubMed
  • Eagleson, K.L., Campbell, D.B., Thompson, B.L., Bergman, M.Y. and Levitt, P: The autism risk genes MET and PLAUR differentially impact cortical development.  Autism Res. 4:68-83, 2011. PubMed
  • Judson, M.C., Eagleson, K.L., Wang, L. and Levitt, P: Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain. J. Comp. Neurol. 518:4463-4478, 2010. PubMed
  • Eagleson, K.L., Gravielle, M.C., Schlueter McFadyen-Ketchum, L.J., Russek, S.J., Farb, D.H. and Levitt, P:  Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes.  Neurosci. 168:797-810, 2010. PubMed
  • Judson, M.C., Bergman, M.Y., Campbell, D.B., Eagleson, K.L. and Levitt, P: Dynamic gene and protein expression patterns of the autism-associated Met receptor tyrosine kinase in the developing mouse forebrain.  J. Comp. Neurol. 513:511-531, 2009. PubMed