Li I Zhang
Dept. of Physiology & Biophysics
Zilkha Neurogenetic Institute
Keck School of Medicine of USC
- Synaptic circuitry mechanisms for sensory information processing
- Technical innovations for tracing brain circuits
- Neural circuits for innate behavior
- Synaptic and cellular basis for development and plasticity of neural circuitry
- Neural circuitry basis for developmental or degenerative neurological diseases
- Cellular and molecular basis for functional development of mammlian cochlear
Research OverviewAs a systems neuroscientist, our ultimate research goal is to decipher the brain circuits, and to understand how perception and behaviors are generated and controlled, how the brain?s cortex adapts in response to changes in the dynamic external environment, and how specific changes in cortical functions result in neurological and psychiatric disorders. To address these highly challenging questions, our approach is to resolve the neural circuitry (how neurons are wired in the brain), i.e. the structural basis underlying the brain functions.
Technical innovation is the key for exploring the dauntingly complex brain circuits. In the past years, we have committed substantial efforts in developing molecular/genetic and electrophysiological/imaging techniques for elucidating the neural circuits for both local neuronal computation and for controlling animal behavior. To this end, we have pioneered in applying in vivo whole-cell voltage-clamp recording, to reveal at the synaptic connection level, how the excitatory and inhibitory synaptic interplay determines the sensory response/processing properties. We have now integrated a broad spectrum of state-of-the-art approaches, including in vivo and in vitro electrophysiology, two-photon Ca2+ imaging, neural modeling, anatomical tracing and optogentics, to build an understanding of neural circuits composed of different cell types.
Los Angeles, CA 90033
- Postdoc, University of California, San Francisco 2004
- PhD, University of California, San Diego, 2000
- MA, Columbia University, 1996
- BS, Peking (Beijing) University, China, 1994
Selected PublicationsView a complete PubMed search
AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.Zingg B, Chou XL, Zhang ZG, Mesik L, Liang F, Tao HW, Zhang LI.Neuron. 2017 Jan 4;93(1):33-47. doi: 10.1016/j.neuron.2016.11.045. Epub 2016 Dec 15.PubMed Link
Auditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus.Xiong XR, Liang F, Zingg B, Ji XY, Ibrahim LA, Tao HW, Zhang LI.Nat Commun. 2015 Jun 11;6:7224. doi: 10.1038/ncomms8224PubMed Link
Zhou M, Liang F, Xiong XR, Li L, Li H, Xiao Z, Tao HW, Zhang LI.
Nat Neurosci. 2014 Apr 20.
Zhou Y, Liu BH, Wu GK, Kim YJ, Xiao Z, Tao HW, Zhang LI.
Neuron. 2010 Mar 11;65(5):706-17.
Sun YJ, Wu GK, Liu BH, Li P, Zhou M, Xiao Z, Tao HW, Zhang LI.
Nature. 2010 Jun 17;465(7300):927-31.
Xiong XR, Liang F, Li H, Mesik L, Zhang KK, Polley DB, Tao HW, Xiao Z, Zhang LI.
Neuron. 2013 Aug 21;79(4):738-53.
Li LY, Li YT, Zhou M, Tao HW, Zhang LI.
Nat Neurosci. 2013 Sep;16(9):1179-81.