Scott E. Kanoski
- Food intake and body weight regulation
- Learning and memory
- Neuroanatomy and circuits
- Cognitive Impairment / Alzheimer's
Research OverviewThe prevalence of obesity has exploded over the past 30 years. The neurobiological systems that underlie the excessive feeding behavior contributing to obesity onset remain poorly understood. Our goal is to explore the neural control of "higher-order" aspects of feeding behavior, including decisions about whether to eat or not to eat, what to consume, and how much of it to consume.
These decisions are heavily influenced by neuroendocrine signals produced in the peripheral organs or in the brain (e.g., leptin, GLP-1, ghrelin, orexin) that act on receptors expressed in the brain's cognitive and reward circuitry. At the center of our research focus is the hippocampus; a region traditionally linked with the control of learning and memory. We've recently shown that the hippocampus regulates higher-order aspects of feeding behavior by detecting and utilizing circulating hormonal signals. Our research approach utilizes neuropharmacological, neuroanatomical, genetic, surgical, behavioral, and other research strategies to explore how neuroendocrine systems act in the hippocampus and other brain areas to increase (or decrease) food-motivated behavior. Our goal is to provide insight into the biology and psychology underlying the excessive food intake that is driving up obesity rates in Western cultures.
A second and related focus of our lab is to study how the brain is negatively impacted by dietary and metabolic factors. Saturated fatty acid and refined carbohydrate (i.e., sugar) consumption not only contributes to obesity development, but also produces deficits in learning and memory capabilities and can even increase the risk for developing Alzheimer's pathology. We are currently examining the specific causal dietary factors and critical developmental periods related to diet-induced hippocampal dysfunction. Our work is revealing underlying neurobiological mechanisms (e.g., blood-brain barrier disruption, neuroinflammation) that link Western diet intake to cognitive impairment.
University of Southern California
Los Angeles, CA 90089-0372
- B.S. Psychology (University of Illinois at Urbana-Champaign, 2000)
- M.S. Psychology (Purdue University, 2006)
- Ph.D. Psychology / Behavioral Neuroscience (Purdue University, 2009)
- Postdoctoral Research Fellow (University of Pennsylvania, 2009-2012)
Selected PublicationsView a complete PubMed search
Gut vagal signaling regulates hippocampus function through multi-order pathways.
Nature Communications. 2018; In Press.Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, Hahn JD, de Lartigue G, Kanoski SEPubMed Link
Control of feeding behavior by cerebral ventricular volume transmission of of melanin-concentrating hormone.
Cell Metabolism. 2018; In Press.
Noble EE, Hahn JD, Konanur VR, Hsu TM, Page SJ, Cortella AM, Liu CM, Song MY, Suarez AN, Szujewski CC, Rider D, Clarke JE, Darvas M, Appleyard SM, Kanoski SELink
A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling.
Molecular Psychiatry. 2018; Epub Ahead of Print.
Hsu TM, Noble EE, Liu CM, Cortella AM, Konanur VR, Suarez AN, Reiner DJ, Hahn JD, Hayes MR, Kanoski SEPubMed Link
Early life sugar consumption affects the microbiome in rodents independent of obesity.
Journal of Nutrition. 2017; 147(1): 20-28
Noble EE, Hsu TM, Jones R, Fodor A, Goran MI, Kanoski SEPubMed Link
Gut to brain dysbiosis: mechanisms linking Western Diet consumption, the microbiota, and cognitive impairment.
Frontiers in Behavioral Neuroscience. 2017; 11(9): 1-10
Noble EE, Hsu TM, Kanoski SEPubMed Link
GLP-1 and weight loss: unraveling the diverse neural circuitry.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2016; 310(10): R885-95.
Kanoski SE, Hayes MR, Skibicka KP
Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways.
eLife. 2015; 14(4)
Hsu TM, Hahn JD, Konanur VR, Noble EE, Suarez AN, Thai J, Nakamoto EN, Kanoski SEPubMed Link
Hippocampal GLP-1 receptors influence food intake, meal size, and effort-based responding for food through volume transmission.
Neuropsychopharmacology. 2015; 40(2):327-37
Hsu TM, Hahn JD, Konanur VR, Lam A, Kanoski SEPubMed Link
Effects of sucrose and high fructose corn syrup on spatial memory function and hippocampal neuroinflammation in adolescent rats.
Hippocampus. 2015; 25(2): 227-39
Hsu TM, Konanur VR, Taing L, Usui R, Kayser BD, Goran MI, Kanoski SEPubMed Link