Sarah W. Bottjer
Dornsife College of Letters Arts & Sciences
- Learning & Memory
- Systems Neuroscience
- Cortex-Basal Ganglia
Research OverviewProcedural skill learning involves goal-oriented evaluation of behavioral outcomes, which gradually shapes neural circuits to select appropriate actions. That is, acquisition of motor skills depends on neural circuits that compare feedback of self-generated movements to a desired goal and reinforce correct movements that match that goal.
Neural circuits that traverse the cortex and basal ganglia mediate diverse types of procedural learning. How they accomplish this feat is not well understood. A significant gap in our understanding of the learning process centers on how circuits compare self-generated movements with behavioral goals and evaluate the outcome.
Vocal learning in songbirds provides a powerful model for studying the control of experience-dependent skill learning by cortico-basal ganglia circuits. Songbirds, like humans, learn the sounds used for vocal communication during a sensitive period of development. Successful learning requires comparing feedback of babbling sounds to a neural memory of vocal sounds learned from social tutors such as parents. We measure the activity and morphology of neurons as juvenile birds produce their own immature vocalizations. In this way we can investigate neural mechanisms underlying the evaluation of self-generated behavior against a memory of sounds learned from a tutor (the goal) in order to guide gradual acquisition of mature stereotyped behavior.
Disorders of the basal ganglia contribute to multiple diseases, including stuttering, Tourette syndrome, obsessive compulsive disorder, addiction, Parkinson's disease, and Huntington's disease. Understanding the normal function of these circuits is a necessary prerequisite to understanding these disease states.
Mailing Address 2520 UPC
Office Location HNB 218
Office Phone (213) 740-9183
Fax (213) 740-5687
Office Location HNB 218
- BA 1975 Psychology - State University of New York, Binghamton, NY
- PhD 1979 Psychology - Indiana University, Bloomington, IN
- Postdoctoral Research Fellowship - 1980-1986 University of California, Los Angeles
Selected PublicationsView a complete PubMed searchView a complete Google Scholar search
- Yuan, R.C., and Bottjer S.W. (2019) Differential developmental changes in cortical representations of auditory-vocal stimuli in songbirds. Journal of Neurophysiology 121(2):530-548. doi: 10.1152/jn.00714.2018. PubMed Link
- Achiro J.M., Shen, J.and Bottjer S.W. (2017) Neural activity in cortico-basal ganglia circuits of juvenile songbirds encodes performance during goal-directed learning. eLife, 2017;6:e26973 doi: 10.7554/eLife.26973. PubMed
- Miller-Sims, V.C., and Bottjer, S.W. (2014) Development of neural responsivity to vocal sounds in higher-level auditory cortex of songbirds. Journal of Neurophysiology 112: 81-94. PubMed
- Paterson A.K., and Bottjer S.W. (2017) Cortical inter-hemispheric circuits for multimodal vocal learning in songbirds. Journal of Comparative Neurology 525: 3312-3340. PubMed
- Achiro JM, and Bottjer, SW (2013) Neural representation of a target auditory memory in a cortico-basal ganglia pathway. Journal of Neuroscience 33: 14475-14488. PubMed
- Miller-Sims, V.C., and Bottjer, S.W. (2012) Auditory experience refines cortico-basal ganglia inputs to motor cortex via re-mapping of single axons during vocal learning. Journal of Neurophysiology 107: 1142-1156. PubMed
- Bottjer SW, Alderete T and Chang D (2010) Conjunction of vocal production and perception regulates expression of the immediate early gene ZENK in a novel cortical region of songbirds. Journal of Neurophysiology 103: 1833-1842. PubMed
- Bottjer SW and Altenau B (2009) Parallel pathways for vocal learning in basal ganglia of songbirds. Nature Neuroscience, 13: 153-155. doi: 10.1038/nn.2472. PubMed
- Bottjer SW (2005) Silent synapses in a thalamo-cortical circuit necessary for song learning in zebra finches. Journal of Neurophysiology 94(6):3698-707. PubMed
- Iyengar, S., and Bottjer, S.W. (2002) The role of auditory experience in the formation of neural circuits underlying vocal learning in zebra finches. Journal of Neuroscience 22: 946-958. PubMed