Alan G. Watts
Department of Biological Sciences
President, The Society for the Study of Ingestive Behaviors
- Systems neuroscience
- Neural control of metabolism
- Ingestive behaviors
Research OverviewOur work is directed towards understanding how the brain contributes to the development, manifestation, and complications of diabetes and obesity. We do this in two projects that focus on the neural control of energy metabolism.
The first project investigates how peripheral metabolism interacts with the brain to generate adrenocortical and sympathoadrenal hormonal responses. In particular, we are interested in the way that two critical metabolic signals--glucocorticoid hormones and blood glucose (glycemia)--are sensed by the brain, and then generate appropriate counter-regulatory responses.
How the brain and the body senses changes in blood glucose is a fundamental physiological process, the understanding of which is critical to the etiolology of both forms of diabetes. We are interested in how glucocorticoids and neurotransmitters interact with neurons in the hypothalamus, which is a major integrative locus for metabolic control. A major focus of our work is on sets of hindbrain catecholaminergic neurons that project to the forebrain. These neurons are crucial for detecting and encoding information about blood glucose levels. We investigate the way that catecholaminergic neurons and glucocorticoids affect signal transduction and gene regulatory mechanisms in sets of forebrain neurons responsible for regulating metabolism in health and disease.
The techniques we use include: whole animal physiology, in situ hybridization, immunocytochemistry (with confocal and conventional immunofluorescence), tract-tracing, behavioral analysis, and neuroinfomatics.
Hedco Neuroscience Building, Rm 416
3641 Watt Way
Los Angeles, CA 90089
- BSc (Hons): University of Wales, UK
- D.Phil: University of Oxford, UK
- Post-Doc: Salk Institute, La Jolla, CA
Selected PublicationsView a complete PubMed searchView a complete Google Scholar search
Jokiaho, A J., Donovan, C.M. & Watts, A.G. (2014). The rate of fall of blood glucose during hypoglycemia determines the necessity of forebrain-projecting catecholaminergic neurons for male rat adrenomedullary responses. Diabetes 68: 2854-65.PubMed
- Bohland, M., Matveyenko, A.V., Saberi, M., Khan, A.M., Watts, A.G. & Donovan, C.M. (2014). Activation of hindbrain neurons is mediated by portal-mesenteric vein glucosensors during slow-onset hypoglycemia. Diabetes 68: 2866-75. PubMed
- Watts, A.G. (2014) How do we know if the brain is wired for type 2 diabetes? Current Diabetes Reports 14: 465. PubMed
- Khan, AM, Walker, EM, Dominguez, N & Watts, AG. (2014) Neural input is critical for arcuate hypothalamic neurons to mount intracellular signaling responses to glycemic challenges in male rats: implications for communication within feeding and metabolic control networks. Endocrinology 155: 405â416. PubMed
- Watts, A.G. & Khan, A.M. (2013) Identifying links in the chain: The dynamic coupling of catecholamines, peptide synthesis, and peptide release in hypothalamic neuroendocrine neurons. Advances in Pharmacology 68: 421-444. PubMed
- Wamsteeker-Cusulin, J.I., Fuzesi T., Watts, A.G., & Bains, J.S. (2013) Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice. PLoS One 8(5): e64943 (pp 1-10). PubMed
- Kaminski, K.L. & Watts, A.G. (2012) Intact catecholamine inputs to the forebrain are required for appropriate regulation of CRH and vasopressin gene expression by corticosterone in the rat paraventricular nucleus. J. Neuroendocrinology 24: 1517-1526. PubMed
- Khan, A.M., Kaminski, K.L., Sanchez-Watts, G., Ponzio T.A., Kuzmiski, J.B., Bains, J.S., & Watts, A.G. (2011) MAP kinases couple hindbrain-derived catecholamine signals to hypothalamic adrenocortical control mechanisms during glycemia-related challenges. J. Neuroscience 31: 18479 â18491. PubMed
- Watts, A.G., Sanchez-Watts, G., Liu, Y. and Aguilera, G. (2011) The distribution of messenger RNAs encoding the three isoforms of the Transducer Of Regulated CREB Activity (TORC) in the rat forebrain. J. Neuroendocrinology 23: 754-766. PubMed
- Watts, A.G. & Donovan, C.M. (2010) Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation. Frontiers in Neuroendocrinology 31: 32-43. PubMed