Jean C. Shih



Cell & Neurobiology, Molecular Pharmacology & Toxicology
Keck School of Medicine
School of Pharmacy

Jean C. Shih

Research Topics

  • Neurobiology of Emotion
  • Autism and brain developmental disorders
  • MAO as Noval target for Cancer Therapeutics
  • Gene regulation and functions
  • Drug discovery and development

Research Overview

Research objectives in Shih Lab are to understand the roles of neurotransmitters on gene expression, signal transduction behaviors and ultimately diseases. They are studying the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out mice, which are animal models for anxiety, aggression and autistic-like-behavior and aggression. Recently, they showed these gene knockout mice also slowed down the progression and metastasis of prostate and brain cancers Thus provides unique animal models to study the interaction between tumors and microenvironment. Currently, Shih Lab used these KO mice model to develop novel targets for the treatment and early diagnosis of autistic-like behaviors and prostate and brain cancer.

Contact Information

Mailing Address 9121 HSC
Office Location PSC 518
Office Phone (323) 442-1441
Lab Location
Lab Phone
Fax (323) 224-7473
Office Location PSC 518



  • BS 1964 Biochemistry - National Taiwan University, Taiwan
  • PhD 1968 Biochemistry - University of California, Riverside
  • Postdoctoral Research Fellowship:
  • 1968 - 1970 University of California, Los Angeles

Selected Publications

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