- Synthetic perception
Research OverviewThe cerebral cortex is the seat of human and mammalian intelligence, and is vital to sensory information processing, pattern recognition and assembly of conscious perception. We seek to understand the role the cortex plays in the processing of tactile sensations and generation of perception. To do so, we record from cortical neurons during quantified behavior, correlate sensory input to neural activity and modify, delete or synthesize perceptions via patterned photostimulation of cortex. In other words, our work aims to provide read, translation and write access to cortical circuits. Ultimately, we seek to develop therapeutic interventions for neurological disorders of sensory processing and tactile feedback systems for prosthetics.
Our research efforts are directed on three related avenues :
1) Determination of how tactile information is represented across the major cell types and layers of somatosensory cortex during tasks that require sensory processing.
2) Development of tools to manipulate activity of functional groups of neurons that represent elemental components of sensation and perception.
3) Construction of increasingly precise and complex synthetic sensations and perceptions via patterned stimulation of functional groups of cortical neurons in the context of active behaviors.
Our primary area of investigation is the mouse somatosensory cortex. This system combines powerful genetic access with exquisite stimulus control in a brain area conserved between humans and other mammals. We employ a variety of innovative technologies, including circuit and cell-type specific closed-loop optogenetic neural control in transgenic and virally transduced mice, whole-cell and juxtacellular electrophysiology, high-density silicon probe based neural recording, and millisecond resolution sensory measurement, all while animals are engaged in active tactile discrimination tasks.
Los Angeles, CA 90089
- MIT : 2001, SB - Brain and Cognitive Sciences
- UCSD : 2007, PhD
- Janelia Farm / HHMI, 2008: Postdoc
- Janelia Farm / HHMI, 2013: Postdoc
Guo ZV, Hires SA, Li N, O'Connor DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S, Xu NL, Cox J, Svoboda K.
PLoS One. 2014 Feb 10;9(2):e88678. doi: 10.1371/journal.pone.0088678. eCollection 2014.
Hires SA, Pammer L, Svoboda K, Golomb D.
Elife. 2013 Nov 19;2:e01350. doi: 10.7554/eLife.01350.
O'Connor DH, Hires SA, Guo ZV, Li N, Yu J, Sun QQ, Huber D, Svoboda K.
Nat Neurosci. 2013 Jul;16(7):958-65. doi: 10.1038/nn.3419. Epub 2013 Jun 2.
- The mechanical variables underlying object localization along the axis of the whisker. Pammer L, O'Connor DH, Hires SA, Clack NG, Huber D, Myers EW, Svoboda K. J Neurosci. 2013 Apr 17;33(16):6726-41. doi: 10.1523/JNEUROSCI.4316-12.2013. PubMed
Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL.
Nat Methods. 2013 Feb;10(2):162-70. doi: 10.1038/nmeth.2333. Epub 2013 Jan 13.
Tian L, Hires SA, Looger LL.
Cold Spring Harb Protoc. 2012 Jun 1;2012(6):647-56. doi: 10.1101/pdb.top069609. Review.
Hooks BM, Hires SA, Zhang YX, Huber D, Petreanu L, Svoboda K, Shepherd GM.
PLoS Biol. 2011 Jan 4;9(1):e1000572. doi: 10.1371/journal.pbio.1000572.
- Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL. Nat Methods. 2009 Dec;6(12):875-81. doi: 10.1038/nmeth.1398. Epub 2009 Nov 8. PubMed
Hires SA, Tian L, Looger LL.
Brain Cell Biol. 2008 Aug;36(1-4):69-86. doi: 10.1007/s11068-008-9029-4. Epub 2008 Oct 22. Review.
Hires SA, Zhu Y, Tsien RY.
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4411-6. doi: 10.1073/pnas.0712008105. Epub 2008 Mar 10.