Meredith Braskie

Assistant Professor

Meredith   Braskie

Research Topics

  • Alzheimer's Disease Risk - Genetic and Environmental
  • Resting State Functional MRI
  • Structural MRI
  • Diffusion Tensor Imaging
  • Inflammation
  • Metabolic risk
  • Amyloid & Tau

Research Overview

My research focuses on neuroimaging Alzheimer's disease (AD) risk and cognitive aging, with an emphasis on preclinical AD and early mild cognitive impairment. We evaluate how genetic and environmental risk factors for AD, especially as relate to inflammation and metabolic risk, affect brain structure, function, and connectivity throughout adulthood. We also seek to understand the biological mechanisms and signaling pathways that may contribute to or protect against AD-related changes; we use relevant blood and cerebrospinal fluid measures, multimodal imaging, and when possible, we engage in collaborative research with laboratories investigating similar concepts in a wet lab environment.

Contact Information

Mailing Address Imaging Genetics Center
Institute for Neuroimaging and Informatics
4676 Admiralty Way
Marina del Rey, CA 90292
Office Location
Office Phone
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  • Postdoc fellow - UCLA & UC Berkeley
  • PhD Neuroscience - UCLA
  • BBA - The College of William and Mary

Selected Publications

  • Corlier F, Hafzalla G, Faskowitz J, Kuller LH, Becker JT, Lopez OL, Thompson PM, Braskie MN Systemic inflammation as a predictor of brain aging: contributions of physical activity, metabolic risk, and genetic risk (2018) NeuroImage 172:118-129. PubMed Link
  • Braskie MN, Boyle CP, Rajagopalan P, Gutman BA, Toga AW, Raji CA, Kuller LH, Becker JT, Lopez OL, Thompson PM. Exercise, TNFa, and volume of the aging brain (2014) Neuroscience 273:199-209.  PubMed Link
  • Braskie MN, Thompson PM. Understanding cognitive deficits in Alzheimer’s disease based on neuroimaging findings (2013) Trends in Cognitive Sciences 17(10): 517-524.  Link
  • Braskie MN, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer SY, Ringman JM. Increased fMRI signal with age in familial Alzheimer’s disease mutation carriers. (2012) Neurobiology of Aging 33(2):424.e11-21 Link
  • Braskie MN, Jahanshad N, Stein JL, Barysheva M, Johnson K, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults (2012) The Journal of Neuroscience 32(17):5964-5972 Link
  • Braskie MN,* Jahanshad N,* Stein JL,* Barysheva M, McMahon KL, de Zubicaray GI, Martin NG,Wright MJ, Ringman JM, Toga AW, Thompson PM. Commonly-carried Alzheimer's disease risk gene, CLU, affects brain fiber microstructure in young adults (2011). The Journal of Neuroscience. 31(18): 6764-6770.  Link
  • Braskie MN, Wilcox CE, Landau SM, O’Neil JP, Baker S, Madison CM, Kluth JT, Jagust WJ. Relationship of striatal dopamine synthesis capacity to age and cognition (2008) The Journal of Neuroscience 28(52):14320-8.  Link
  • Braskie MN, Thompson  PM. A focus on structural brain imaging in the Alzheimer's Disease Neuroimaging Initiative (2014) Biological Psychiatry. 75(7):527-33.  Link
  • Braskie MN, Small GW, Bookheimer SY. Entorhinal cortical thickness and functional MRI response during a verbal memory task (2009) Human Brain Mapping 30(12):3981-3982.  Link
  • Braskie MN,  Klunder AD,  Hayashi KM, Protas H, Kepe V, Miller KJ, Huang S-C, Barrio JR,  Ercoli LM, Siddarth P, Satyamurthy N, Liu J, Toga AW, Bookheimer SY, Small GW, Thompson PM. Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease (2010) Neurobiology of Aging 31(10): 1669-78.  Link