Bruce E. Herring

Assistant Professor

Bruce  E. Herring

Research Topics

  • Synaptic function
  • Synaptic plasticity
  • Neuropsychiatric and Neurodevelopmental Disorders

Research Images

Research Overview

We combine innovative genetic approaches with electrophysiology and super-resolution imaging techniques to gain insight into the molecular underpinnings of mammalian synaptic function. More specifically, my lab is interested in the molecular mechanisms governing synaptic plasticity and how dysregulation of these mechanisms gives rise to neuropsychiatric and neurodevelopmental disease.

Contact Information

Mailing Address University of Southern California
University Park Campus
3641 Watt Way
M/C 2520
Los Angeles, CA 90089-2520
Office Location HNB 328
Office Phone (213) 740-6328
Lab Location
Lab Phone
Office Location HNB 328



  • Ph.D., University of Chicago
  • Postdoctoral training: UCSF

Selected Publications

View a complete PubMed search
  • Herring BE and Nicoll RA (2016) Kalirin and Trio serve critical roles in excitatory synaptic transmission and LTP. (Proceedings of the National Academy of Sciences, In Press)
  • Herring BE and Nicoll RA (2016) Long-Term Potentiation: From CaMKII to AMPA receptor trafficking. (Annual Review of Physiology, In Press)
  • Herring BE*, Silm K*, Edwards RH, Nicoll RA. (2015) Is Aspartate an excitatory neurotransmitter? Journal of Neuroscience. 35(28): 10168-71. (*co-first authors) PubMed
  • Choy RW*, Park M*, Temkin P, Herring BE, Nicoll RA, von Zastrow M (2014) Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 82(1): 55-62. (*co-first authors) PubMed
  • Bemben MA, Shipman SL, Hirai T, Herring BE, Li Y, Badger JD, Nicoll RA, Roche KW (2013) CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nature Neuroscience. 17(1): 56-64. PubMed
  • Shipman SL, Herring BE, Suh YH, Roche KW and Nicoll RA (2013) Distance dependent scaling of AMPARs is cell-autonomous and GluA2-dependent. Journal of Neuroscience. 33(33): 13312-19. PubMed
  • Herring BE*, Shi Y*, Suh YH, Zheng CY, Blankenship SM, Roche KW, Nicoll RA (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 77(6): 1083-96. (*co-first authors) PubMed
  • Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA and Roche KW (2012) Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proceedings of the National Academy of Sciences. 109(47):19426-19431. PubMed
  • Herring BE, McMillan K, Pike CM, Marks J, Fox AP and Xie Z (2011) Etomidate and propofol inhibit the neurotransmitter release machinery at different sites. Journal of Physiology. 589(5):1103-15. PubMed
  • Herring BE, Zheng X, Marks J, and Fox AP (2009) Isoflurane inhibits the neurotransmitter release machinery. Journal of Neurophysiology. 102(2):1265-73. PubMed