S. Duke Han

Director, Neuropsychology Division
Department of Family Medicine
Professor of Family Medicine, Neurology, Psychology, and Gerontology
USC Keck School of Medicine

S. Duke  Han

Research Topics

  • Cognition
  • Decision Making
  • Aging
  • Neuropsychology
  • Neuroimaging

Research Images

Cluster indicating less grey matter in medial temporal lobe associated with susceptibility to scams (Han et al., in press, Brain Imaging and Behavior)Voxelwise results of fractional anisotropy (FA) positive association with financial literacy in linear regression models adjusted for age, education, sex, white matter hyperintensities and cognitive function (Han et al., 2016, NeuroImage)Functionally connected clusters associated with financial literacy after adjusting for age, education, sex, and global cognition, as indicated by a seed ROI prescribed in
the PCC. Seed ROI MNI coordinates: x = 0, y = -53, z = 26; radius = 4 mm; voxel p < 0.004. Corrected for multiple comparisons using AlphaSim Monte Carlo simulations at a
cluster level threshold of p < 0.0002 (cluster size > 75 voxels). Values shown in scale correspond to t-scores (Han et al., 2014, Archives of Geriatrics and Gerontology)Magnitude and direction of voxel-level activation to a verbal-paired associate learning task superimposed onto axial slices of a representative image in Taliarach space (slices span from 19 inferior to 56 superior in 4mm increments). Activation displayed includes voxels significant at p < 0.025 that are contained within a cluster of 15 or more voxels (Han et al., 2007, Neurobiology of Aging).

Research Overview

Dr. Duke Han is a diplomate of the American Board of Professional Psychology in clinical neuropsychology, Director of Neuropsychology in the Department of Family Medicine, and a tenured Professor of Family Medicine, Neurology, Psychology, and Gerontology at the Keck School of Medicine of the University of Southern California. Dr. Han is interested in the study of factors that impact cognition and decision making in aging. He also has special interests in using novel neuroimaging and statistical approaches to better understand these factors. Dr. Han maintains an active research collaboration with the Rush Alzheimer's Disease Center of Rush University Medical Center in Chicago, where he was most recently a tenured faculty member and continues to retain a visiting professor status. He was the recipient of the prestigious Paul B. Beeson Career Development Award in aging research, which is supported by the National Institute on Aging (NIA), the American Federation of Aging Research (AFAR), and the John A. Hartford Foundation. Dr. Han is actively involved in peer-review of aging and Alzheimer?s Disease research grants for the NIH, and is currently serving as the Chair of the NIA Clinical and Translational Research of Aging Review Committee (NIA-T). He reviews manuscripts for over 30 scientific journals and is on the editorial board for the Journal of Alzheimer?s Disease and Archives of Clinical Neuropsychology. Dr. Han is an inaugural Governance Committee member of the Global Council for Brain Health, an independent science collaborative convened by the AARP with support from AgeUK tasked to summarize scientific knowledge regarding brain health topics for the aging public. Dr. Han currently serves as an oral examiner for the clinical neuropsychology board certification process and holds leadership or mentorship roles in the International Neuropsychological Society (INS), the National Academy of Neuropsychology (NAN), the American Academy of Clinical Neuropsychology (AACN), and the Society of Clinical Neuropsychology (Division 40) of the American Psychological Association.

Contact Information

Mailing Address Department of Family Medicine
USC Keck School of Medicine
1000 S. Fremont Avenue, Unit 22
HSA Building A-6, 4th Floor, Room 6437A
Alhambra, CA 91803
Office Location Alhambra
Office Phone (626) 457-5858
Lab Location Alhambra
Lab Phone
Fax (626) 457-4090
Office Location Alhambra



  • Postdoctoral Fellowship: UCSD/VA San Diego
  • Internship: UCSD/VA San Diego
  • PhD: University of Massachusetts Boston
  • Bachelors of Science & Neuroscience Certificate: Duke University

Selected Publications

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  • Han, S.D., Boyle, P.A., Arfanakis, K., Fleischman, D.A., Yu, L., James, B.D., & Bennett, D.A. Financial literacy is associated with white matter integrity in old age.  NeuroImage. 130: 223-229, 2016.

  • Han, S.D., Boyle, P.A., Yu, L., Arfanakis, K., James, B.D., Fleischman, D.A., & Bennett, D.A. Grey matter correlates of susceptibility to scam in community-dwelling older adults.  Brain Imaging and Behavior.

  • Han, S.D., Boyle, P.A., James, B.D., Yu, L., & Bennett, D.A. Mild cognitive impairment and susceptibility to scams in old age.  Journal of Alzheimer’s Disease. 49: 845-851, 2016.

  • Han, S.D., Boyle, P.A., Yu, L., Fleischman, D.A., Arfanakis, K., Leurgans, S., & Bennett, D.A., Financial literacy is associated with medial brain region functional connectivity in old age.  Archives of Gerontology and Geriatrics. 59: 429‐438, 2014.

  • Han, S.D., Boyle, P.A., Yu, L., Fleischman, D.A., Arfanakis, K., & Bennett, D.A.,  Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Experimental Gerontology. 48: 1489‐1498, 2013. PubMed
  • Han, S.D., Gruhl, J.C., Beckett, L., Dodge, H.H., Stricker, N.H., Farias, S., & Mungas, D., Beta amyloid, tau, neuroimaging, and cognition: Sequence modeling of biomarkers for Alzheimer's disease. Brain Imaging and Behavior. 6: 610‐620, 2012.

  • Han, S.D., Boyle, P.A., Arfanakis, K., Fleischman, D., Yu, L., Edmonds, E.C.*, & Bennett, D.A., Neural intrinsic connectivity networks associated with risk aversion in old age. Behavioural Brain Research. 227: 233‐240, 2012.

  • Tuminello, E.R.*, & Han, S.D., The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations.  The International Journal of Alzheimer’s Disease. Article ID 726197, 12 pages, 2011.

  • Han, S.D., Arfanakis, K., Fleischman, D., Leurgans, S., Tuminello, E.R.*, Edmonds, E.C.*, & Bennett, D.A., Functional connectivity variations in mild cognitive impairment: Associations with cognitive function.  Journal of the International Neuropsychological Society. 18: 39-48, 2012.

  • Han, S.D., Houston, W.S., Jak, A.J., Eyler, L.T., Nagel, B.J., Fleisher, A.S., Brown, G.G., Corey-Bloom, J., Salmon, D.P., Thal, L.J., & Bondi, M.W., Verbal paired-associate learning by APOE genotype in nondemented adults: fMRI evidence of a right hemispheric compensatory response.  Neurobiology of Aging. 28(2): 238‐247, 2007.