Sarah F. Hamm-Alvarez



Pharmaceutical Sciences, Physiology & Biophysics, Ophthalmology
Keck School of Medicine
School of Pharmacy

Sarah F. Hamm-Alvarez

Research Topics

  • Cell Structure & Organization
  • Membranes & Transport
  • Vision Research
  • Drug Design
  • Delivery
  • Physiology

Contact Information

Mailing Address 9121 HSC
Office Location McKibben Addition
Office Phone (323) 442-1445
Lab Location
Lab Phone
Fax (323) 442-1390
Office Location McKibben Addition


  • BA 1986 Chemistry - Carleton College, Northfield, Minnesota
  • PhD 1990 Biochemistry - Duke University, Durham, North Carolina
  • Postdoctoral Research Fellowship:
  • 1990 - 1993 Duke University, Durham, North Carolina

Selected Publications

View a complete PubMed searchView a complete Google Scholar search
  • Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W.  TEAR CATHEPSIN S AS A CANDIDATE BIOMARKER FOR SJOGREN'S SYNDROME.  Arthritis Rheumatol [2014] Jul;66(7):1872-1881. PubMed Link
  • Chiang L,Ngo J,Schechter JE,Karvar S,Tolmachova T,Seabra MC,Hume AN,Hamm-Alvarez SF - RAB27B REGULATES EXOCYTOSIS OF SECRETORY VESICLES IN ACINAR EPITHELIAL CELLS FROM THE LACRIMAL GLAND. - Am J Physiol Cell Physiol [2011] Apr 27;() PubMed Link
  • Li X,Wu K,Edman M,Schenke-Layland K,MacVeigh-Aloni M,Janga SR,Schulz B,Hamm-Alvarez SF - Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. - Invest Ophthalmol Vis Sci [2010] Oct;51(10):5019-29 Link
  • Contreras J,Xie J,Chen YJ,Pei H,Zhang G,Fraser CL,Hamm-Alvarez SF - Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. - ACS Nano [2010] May 25;4(5):2735-47 Link
  • Yacobi NR,Malmstadt N,Fazlollahi F,DeMaio L,Marchelletta R,Hamm-Alvarez SF,Borok Z,Kim KJ,Crandall ED - Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. - Am J Respir Cell Mol Biol [2010] May;42(5):604-14 Link
  • Schenke-Layland K,Xie J,Magnusson M,Angelis E,Li X,Wu K,Reinhardt DP,Maclellan WR,Hamm-Alvarez SF - Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sj√∂gren's syndrome-like exocrinopathy. - Exp Eye Res [2010] Feb;90(2):223-37 Link
  • Kim YH,Fazlollahi F,Kennedy IM,Yacobi NR,Hamm-Alvarez SF,Borok Z,Kim KJ,Crandall ED - Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. - Am J Respir Crit Care Med [2010] Dec 1;182(11):1398-409
  • Wu K,Joffre C,Li X,MacVeigh-Aloni M,Hom M,Hwang J,Ding C,Gregoire S,Bretillon L,Zhong JF,Hamm-Alvarez SF - Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. - Exp Eye Res [2009] Sep;89(3):319-32 Link
  • Xie J,Marchelletta RR,Thomas PB,Jacobs DT,Yarber FA,Cheney RE,Hamm-Alvarez SF,Trousdale MD - Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. - Exp Eye Res [2009] Mar;88(3):467-78 Link
  • Joo KI,Lei Y,Lee CL,Lo J,Xie J,Hamm-Alvarez SF,Wang P - Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. - ACS Nano [2008] Aug;2(8):1553-62 Link