Our laboratory studies the construction and dynamics of complex genetic networks that underlie circadian rhythms in humans, animals and plants. We also develop and use cutting-edge technologies for measuring transcription in live cells, tissues and intact organisms. We use large scale datasets of gene expression or protein content combined with genetics, bioinformatics and computational tools (mathematical modeling), chemical screens and more conventional biochemical approaches. Ultimately our aim is to scale our understanding of the dynamics of circadian clocks from the systems level down to atomic resolution mechanism. We have a strong commitment to translation of our research, in the case of humans for novel cancer drug discovery. We are currently focussing on targeting clock proteins in glioblastoma stem cells, in order to develop novel therapeutics.
Our laboratory studies the construction and dynamics of complex genetic networks that underlie circadian rhythms in humans, animals and plants. We also develop and use cutting-edge technologies for measuring transcription in live cells, tissues and intact organisms. We use large scale datasets of gene expression or protein content combined with genetics, bioinformatics and computational tools (mathematical modeling), chemical screens and more conventional biochemical approaches. Ultimately our aim is to scale our understanding of the dynamics of circadian clocks from the systems level down to atomic resolution mechanism. We have a strong commitment to translation of our research, in the case of humans for novel cancer drug discovery. We are currently focussing on targeting clock proteins in glioblastoma stem cells, in order to develop novel therapeutics.
