Histology

Eagleson, Kathie

Associate Professor of Research Pediatrics and Neurology

Research projects investigate the development of brain architecture that controls social-emotional behavior and learning, and how early life experiences impact neurodevelopment. Genetic and environmental factors that regulate circuit and synapse formation are studied at the molecular and circuit level, using single cell and bulk RNA sequencing, viral circuit tracing, and multiplex in-situ hybridization. Preclinical mouse models use exposure to early adverse experiences to study age- and sex- specific mitochondrial adaptations that impact the emergence of cognitive, social and emotional behaviors across the lifespan.

Gnedeva, Ksenia

Assistant Professor of Otolaryngology - Head and Neck Surgery and Stem Cell Biology & Regenerative Medicine

Our perception of the environment relies on specialized cellular receptors residing in epithelial sensory organs. While olfactory and gustatory receptor cells are naturally reproduced throughout life in order to sustain the senses of smell and taste, age-related degeneration of retinal, auditory, and vestibular sensory organs is largely irreversible in humans. In the Gnedeva laboratory, we interrogate how molecular signaling and tissue mechanics control embryonic sensory organ growth and how the developmental programs of self-renewal and differentiation can be re-initiated in the mammalian inner ear after damage. Although the focus of our research is on hearing and balance restoration, our lab has broader interest in the common mechanisms that suppress regeneration in specialized sensory tissues.

Hahn, Joel

Associate Professor (Research) of Biological Sciences

The overall goal / objective of my research is to increase scientific understanding of the fundamental structure/function relations of the nervous system. Using a variety of research methods, I have investigated neural circuits relating to specific functions (for example, neuroendocrine control of reproduction, eating, and agonistic behaviors), as well as high-level global network organization of the brain. My current research is geared mostly to developing and investigating nervous system network models, and to building tools and resources for systems neuroscience, and more recently for comparing neuroanatomical ontologies within and between species, to simplify and enable more accurate interpretation and communication of neuroscience data.

Hires, Samuel Andrew

Associate Professor of Biological Sciences

The Hires lab is investigating the basis of biological intelligence. Over the past decade we developed numerous imaging tools to record large-scale patterns of neural activity that are used by thousands of neuroscience labs. These have resulted in hundreds of publicly available datasets embedded with rich representations of neural activity. We are now developing analytical tools, using recent AI developments, to ultimately distill undiscovered principles of biological intelligence from these datasets.

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