Kalluri, Radha
Associate Professor of Otolaryngology
Physiology of the Inner Ear Laboratory focuses on understanding the physical and physiological mechanisms underlying sensory transduction in the inner ear, with the ultimate goal of understanding how disease and injury impair function. The lab. studies sensory transduction in the auditory and vestibular systems both at the cellular and system level using electrophysiology and biophysical modeling. Our work relies heavily on the interplay between quantitative analysis, theoretical modeling and experimental neuroscience.
Kim, Hosung
Associate Research Professor of Neurology
Currently, we are particularly focused on the morphometry of the perivascular space and non-invasive measurement of Glymphatic flow (a water flow system in the brain that helps clear waste products and toxins) using MRI and artificial intelligence. This research enhances our understanding of the underlying mechanisms involved in sleep disorders, accelerated brain aging due to poor sleep and impaired Glymphatic function, and neurodegenerative diseases such as Alzheimer's disease and other forms of dementia. Dr. Hosung Kim serves as the PI of NIDLL, and guides and coordinates the research efforts of the lab members. We welcome you to join the lab and participate in our valuable research.
Lee, Changhan David
Associate Professor of Gerontology
The Lee Lab investigates how metabolism regulates aging and age-related diseases, including Alzheimer’s, with a focus on mitochondrial communication. Traditionally viewed as end-stage organelles, mitochondria are now recognized as active signaling hubs. We study newly discovered bioactive microproteins encoded in the mitochondrial genome—particularly within the 12S rRNA region—that act as innate signals influencing cell and organismal physiology. These microproteins function both within and between cells and may serve as mitochondrial longevity genes and therapeutic targets. Our work bridges molecular biology and whole-organism physiology to uncover how mitochondria influence aging from within. Students interested in metabolism, mitochondrial biology, and translational aging research will find rich opportunities here.
Lee, Darrin Jason
The focus of my laboratory is to explore the underlying mechanisms and potential of neuromodulation for cognitive dysfunction and psychiatric disorders, such as Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, obsessive compulsive disorder and schizophrenia. Specifically, we utilize multiple depth electrode local field potential recordings and functional ultrasound imaging to evaluate simultaneous electrophysiology, cerebral blood flow and functional connectivity in these disorders. Using these tools, our goal is to better understand the underlying pathophysiology and optimize our neuromodulation strategies. Our aim is to translate our preclinical findings into clinically relevant neuromodulation treatments. My clinical research is focused on evaluating potential new indications and targets for neuromodulation, such as deep brain stimulation (DBS), spinal cord stimulation and focused ultrasound.
Lee, Sun Young
Associate Professor of Ophthalmology and Physiology and Neuroscience
LeeRetinaLab investigates the pathobiology of age-related macular degeneration and diabetic retinopathy, with a focus on developing extracellular vesicle (EV)-based therapeutics. Our team has expertise in small EV (sEV) isolation, characterization, and bioengineering, and we regularly work with relevant animal models. To optimize sEV-based intraocular therapies, we apply both conventional and advanced technologies, including single-particle analysis, nano-flow cytometry, digital PCR, cryo-EM, and multi-omics approaches (transcriptomics, proteomics, lipidomics, and metabolomics). We take a multidisciplinary approach and collaborate closely with experts in bioengineering, regenerative medicine, and gene therapy to accelerate translational outcomes and therapeutic innovation in retinal disease research.
Liew, Sook-Lei
Associate Professor of Biokinesiology and Physical Therapy
The overall mission of the laboratory is to enhance neural plasticity in a wide population of individuals in order to improve their quality of life and engagement in meaningful activities. We particularly focus on individuals with stroke using big data neuroimaging approaches, along with noninvasive brain stimulation and brain computer interfaces.
