Moore, Jeffrey
Assistant Professor of Biological Sciences
Many mammals sense and affect their environment predominantly through innate motor programs for exploration, social interaction, and ingestion; yet, little is known about the neuronal circuits that control these motor programs. Our lab uses molecular, systems, and computational neurobiological techniques to identify specific brainstem motor control modules and to determine how higher-order brain structures engage these modules for innate behaviors.
Oghalai, John
Our research is designed to better understand the fundamental changes in the inner ear that underlie progressive hearing loss and to develop novel techniques to treat this problem before it leads to a severe disability. We strive to understand the biological mechanisms of hearing loss and then translate this knowledge to directly and rapidly improve the care of patients with hearing loss.
Pike, Christian
Research in the Pike Lab is broadly focused on Alzheimer’s disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational strategies for the prevention and treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, rodent models, and cultured cells. Current areas of research focus in the Pike Lab include the contributions of the genetic risk factor APOE4 to AD pathogenesis, sex differences in AD, and the protective efficacy of longevity-promoting interventions including fasting mimicking diet and candidate compounds. We seek to identify and elucidate the mechanisms underlying AD risks and use this information to develop therapeutic interventions.
Schier, Lindsey
Associate Professor of Biological Sciences
The Schier lab seeks to understand how the chemical constituents of foods and fluids are sensed, how these oral and postoral signals are processed in the brain and channeled into the behavioral outputs that subserve energy balance.
Schwartzman, Jessica
Assistant Professor of Clinical Pediatrics
The Training and Research to Empower NeuroDiversity (TREND) Lab uses multi-method approaches, including electroencephalogram (EEG), behavioral observation and clinical interviews to study risk and protective factors for depression, suicide, and other mental health outcomes in youth with autism and other neurodivergent conditions. We also partner with autistic and other neurodivergent people to adapt and design treatments for the individual and family. The TREND Lab focuses on characterizing and treating adverse mental health outcomes in youth with autism and other neurodivergent conditions.
Shera, Christopher
Professor of Otolaryngology-Head and Neck Surgery
The peripheral auditory system transforms air-borne pressure waves into neural impulses that are interpreted by the brain as sound and speech. The cochlea of the inner ear is a snail-shaped electro-hydromechanical signal amplifier, frequency analyzer, and transducer with an astounding constellation of performance characteristics, including sensitivity to sub-atomic displacements with microsecond mechanical response times; wideband operation spanning three orders-of magnitude in frequency; and an input dynamic range of 120 dB, corresponding to a million-million-fold change in signal energy. All of this is achieved not with the latest silicon technology but by self-maintaining biological tissue, most of which is salty water. How does the ear do it? To address this question, we exploit the ear's curious ability to make sound while listening to sound.
