Behavior

Immordino-Yang, Mary Helen

Professor of Education, Psychology & Neuroscience

Professor Mary Helen Immordino-Yang is the Director of USC CANDLE (Center for Affective Neuroscience, Development, Learning and Education). CANDLE’s mission is to bring developmental affective neuroscience into partnership with educational innovation, and to use what is learned to guide the transformation of schools, policy, and the student and teacher experience for a healthier and more equitable society. Our research involves analyzing multi-modal data, including functional and structural neuroimaging (MRI, EEG), and psychophysiological data, from mixed-method studies of adolescent development and effective teaching. During the 2025-2026 academic year, CANDLE will be designing, developing stimuli and collecting data for an upcoming longitudinal study of adolescents’ brain and psychosocial development.

Itti, Laurent

Professor of Computer Science and Psychology

The main fundamental research focus of the lab is in using computational modeling to gain insight into biological brain function. Thus, we study biologically-plausible brain models, and we compare the predictions of model simulations to empirical measurements from living systems. The brain subsystem towards which most of our efforts are focused is the visual system. Our modeling efforts range from fairly detailed models of small neuronal circuits, such as a single hypercolumn of orientation-selective neurons in primary visual cortex, to large-scale models embodying several million highly-simplified neurons to explore mechanisms of visual attention, gaze control, object recognition, and goal-oriented scene understanding. Further, we strive to employ modeling principles which are mathematically optimal in some task- and goal-dependent sense. Thus, we are interested in investigating the tasks and conditions for which the biological brain approaches the theoretical limits of information processing.

Jakowec, Michael

Professor of Clinical Pharmacy (Teaching)

The primary focus of research in Dr. Jakowec’s laboratory is to better understand the underlying molecular mechanisms involved in neuroplasticity in the injured brain with the emphasis on the basal ganglia and prefrontal cortex, regions of the brain responsible for motor and cognitive behaviors.The overarching goal is to find improved therapeutic approaches for brain disorders especially Parkinson’s disease and drug addiction. For the past 20 years the laboratory has examined the effects of exercise on promoting neuroplasticity, particularly synaptogenesis in animal models of Parkinson’s disease. In addition to non-pharmacological approaches to promote brain repair, ongoing studies are using an experimental therapeutics approach to explore pharmacological interventions to determine if novel drugs can serve as a means to enhance brain repair, especially in the context of exercise. Recent studies have focused on the mechanisms by which astrocytes support neuronal function as well as mechanisms by which boosting mitochondrial integrity can promote improved functional connectivity and restoration of motor and cognitive behaviors.

Kalluri, Radha

Associate Professor of Otolaryngology

Physiology of the Inner Ear Laboratory focuses on understanding the physical and physiological mechanisms underlying sensory transduction in the inner ear, with the ultimate goal of understanding how disease and injury impair function. The lab. studies sensory transduction in the auditory and vestibular systems both at the cellular and system level using electrophysiology and biophysical modeling. Our work relies heavily on the interplay between quantitative analysis, theoretical modeling and experimental neuroscience.

Kamitakahara, Anna

Assistant Professor of Research

Research in the Kamitakahara Laboratory investigates how genes and the environment shape the development and mature function of the neural circuits controlling feeding behavior. Specific topics examined include: 1) the impact of perinatal nutrition on gut-brain signaling of satiation and reward-based feeding behaviors, and 2) the genetic and biological contributions to inter-individual differences in response to GLP-1 receptor agonist treatment. Mechanistic understanding of neural activity and feeding behavior is probed using advanced techniques such as bulk and single cell RNA sequencing, highly multiplexed in situ hybridization, and metabolic cage phenotyping. Through delineation of the genes and dietary factors that shape feeding behavior, research in the Kamitakahara lab aims to provide insight into the biological mechanisms underlying overconsumption and cardiometabolic disease.

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