Aziz-Zadeh, Lisa
Associate Professor of Occupational Science, Psychology and Neurology
The Center for the Neuroscience of Embodied CognitionWe explore how rudimentary sensory-motor areas may be intrinsically involved in processing aspects of higher cognition such as language, thought, emotions, empathy, and social communication. We study both typical populations and autism, using MRI and behavioral studies, also integrating microbiome research.
Baker, Laura A.
Gene-environment interplay in human behavior, including personality, cognitive and social development. Rich datasets from longitudinal twin study of risk factors for externalizing behavior problems available for analysis.
Boato, Francesco
The Functional Repair and Axonogenesis (FRA) lab investigates how the central nervous system (CNS) is wired during development and how these pathways can be reactivated and modulated to promote repair after injury, particularly in the spinal cord and optic nerve. We study growth pathways, axon guidance cues, and neuron-glia interactions that shape connectivity in the CNS. By combining genetic, molecular, behavioral and advanced imaging approaches, we examine neuronal migration, synaptogenesis, and responses to injury. Our goal is to uncover fundamental mechanisms that can be leveraged to drive regeneration, circuit formation and functional recovery in neurological disorders. Trainees will join a collaborative, interdisciplinary environment and will gain experience at the interface of developmental neurobiology and CNS regeneration.
Bonaguidi, Michael
Associate Professor of Stem Cell and Regenerative Medicine
Cognitive impairment (CI) is a burdensome neurological condition that occurs during aging, Alzheimer’s disease (AD), and is a common co-morbidity in many neurodegenerative diseases, including epilepsy. Unfortunately, CI prevalence continues to accelerate due to population aging and emerging therapies only slows CI by a few months. Our research seeks to develop regenerative medicine and provide longer-lasting benefits to CI through brain restoration. We are establishing endogenous brain regeneration as a therapeutic approach for CI in pre-clinical animals and people by (1) investigating neural stem cell behavior in aging, AD and epilepsy, (2) developing computational/AI drug discovery tools for precision medicine to treat CI, and (3) partnering with physicians for human research and clinical trials to translate our findings.
Chen, Jeannie
Professor of Physiology and Neuroscience
The major focus of my laboratory is to study sensory neuron signaling and mechanisms of retinal degeneration and neurodegeneration using cell culture and rodent models. Through interdisciplinary collaboration, we deciphered basic mechanisms of sensory neuron signal transduction and disease pathogenesis in retinal degeneration and neurodegeneration where protein mis-folding and aggregation is an underlying cause of disease.
Ching, Christopher
Assistant Professor Of Research Neurology
Dr. Ching’s research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, he designs and implements standardized processing and analysis techniques for large-scale neuroimaging studies. He leads the ENIGMA Bipolar Disorder Working Group, an effort pooling data and resources from around the world to improve our understanding of the biological processes driving bipolar disorder, and studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how genetic mutations can lead to increased risk for developing psychiatric illness. He leads several large-scale transdiagnostic neuroimaging and genomic initiatives using machine learning to map common and distinct brain and clinical factors across mental illnesses.
